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A pilonidal cyst starts as a small sac or pocket of skin that has become clogged with oil and skin debris. Pimple on anus causes. They can grow large, but tend to be painless. Salicylic acid Virasal, Salex is used to treat acne, warts, psoriasis and other skin conditions. Benzoyl peroxide Benzoyl kills the bacteria causing pimples. Pimples tend to be skin problems most associated with the face, though they can form on your back, pubic area, and just about anywhere on the body — including the anus. Sometimes, a hemorrhoid can bleed. November 13, Last Revised: The American Cancer Society medical and editorial content team Our team is made up of doctors and master's-prepared nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.